The skin is a living organ on the surface of which micro-organisms (several hundred species of bacteria, fungi, viruses and mites) naturally proliferate. All of these microorganisms constitute the skin microbiome, also known as commensal flora. In healthy skin, this microbiome lives in symbiosis with our skin cells. This constitutes a real ecosystem, which interacts and self-regulates to maintain its balance and preserve the health of your skin. But when the microbiome is unbalanced (this is called dysbiosis), it can lead to the appearance of skin pathologies.

Graphic representation of the microbiome of irritated and itchy skin

Among all the microorganisms living in the skin microbiome, one bacterium (Staphylococcus aureus) is found in all individuals. However, in patients with atopic dermatitis, staphylococcus aureus is present, at the level of the lesions, in excessive numbers on the skin surface, creating a real imbalance in the skin ecosystem (1). This bacterium colonizes certain areas of atopic skin in the form of a biofilm.

(1) Edslev SM, Agner T, Andersen PS. Skin Microbiome in Atopic Dermatitis. Acta Derm Venereol. 2020;100(12):adv00164.

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Biofilm formation starts with the adhesion of a bacterium (Staphylococcus aureus in atopic dermatitis) on the surface of the skin, which multiplies to form micro-colonies and produces a substance that envelops them, allowing them to proliferate to the detriment of other types of microorganisms.

Clinical studies have shown that the larger the staphylococcus aureus biofilm, the more frequent and intense the flare-ups associated with atopic dermatitis (2).

(2) Geoghegan JA, Irvine AD, Foster TJ. Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship. Trends Microbiol. 2018;26(6):484-97.

Concerned to meet the needs for the patients, Laboratoire Bioderma developed a patented technology called Skin Barrier Therapy. This patented technology reduces the proliferation of the Staphylococcus aureus in the form of biofilm in order to help rebalance the skin ecosystem of patients with atopic eczema. That’s why it is at the heart of the formulas of all our Atoderm Intensive products (and some Atoderm’s hygiene products such as shower oil) dedicated to irritated to atopic sensitive skin.

An in vitro study conducted on Atoderm Intensive baume showed a 99.9% reduction in the proliferation of Staphylococcus aureus in the form of biofilm after 4 hours.

This targeted efficacy contributes to the excellent results observed in a clinical study conducted on 130 atopic children versus placebo: 6 months without flare-ups for 76% of patients (3).

True to the NAOS ecobiological approach, Atoderm Intensive baume addresses the biological causes of skin imbalance to provide lasting benefits. Atoderm Intensive baume supports patients with atopic dermatitis by helping to reduce the intensity and frequency of flare-ups in the long term. Thus, it plays an essential role in the sustainable improvement of the quality of life of patients.

(3) Gayraud F, Sayag M, Jourdan E. Efficacy and tolerance assessment of a new type of dermocosmetic in infants and children with moderate atopic dermatitis. J Cosmet Dermatol. 2015;14(2):107-12.
Women with the Atoderm Intensive ultra soothing balm.